EZH1 antibody (AA 160-280)

Catalog No. ABIN7155474

The Rabbit Polyclonal anti-EZH1 antibody has been validated for ELISA and IHC. It is suitable to detect EZH1 in samples from Human.

Quick Overview for EZH1 antibody (AA 160-280) (ABIN7155474)

Target: EZH1 (Enhancer of Zeste Homolog 1 (EZH1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EZH1 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Product Details anti-EZH1 Antibody

Binding Specificity: AA 160-280

Purpose: EZH1 Antibody

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Histone-lysine N-methyltransferase EZH1 protein (160-280AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for EZH1

Target: EZH1 (Enhancer of Zeste Homolog 1 (EZH1))

Alternative Name: EZH1

Background:

Background: Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH1 complex, which methylates \\\'Lys-27\\\' of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate \\\'Lys-27\\\' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Required for embryonic stem cell derivation and self-renewal, suggesting that it is involved in safeguarding embryonic stem cell identity. Compared to EZH2-containing complexes, it is less abundant in embryonic stem cells, has weak methyltransferase activity and plays a less critical role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation.

Aliases: Enhancer of zeste homolog 1 (Drosophila) antibody, Enhancer of zeste homolog 1 antibody, ENX-2 antibody, ENX2 antibody, Ezh1 antibody, EZH1_HUMAN antibody, Histone-lysine N-methyltransferase EZH1 antibody

UniProt: Q92800